Performance
Define S2 was a solid performer, but Meshify S2's frontage naturally aids airflow, resulting in slightly cooler temps. Our eight-core Ryzen processor is more than happy.
Cooling the Radeon RX 580 graphics card tends to be a bigger challenge, but Meshify S2 is more than up to the task and is only the fourth chassis to be able to keep core temp to 70ºC when gaming.
There is a slight increase in noise, mind. Meshify S2 is by no means a loud case - the integrated fan controller sees to that - but it isn't clearly as quiet as the sound-dampened counterpart, the Define S2.